Originally called the Philippine Anti-Tuberculosis Society, it was founded on July 29, 1910 by a group of Filipinos and American residents dedicated to the prevention, treatment and control of tuberculosis (TB) in the country. It was subsequently incorporated as Philippine Tuberculosis Society Inc. (PTSI) on February 29, 1960 and was registered with the SEC on March 11, 1960 as a non-stock, non-profit organization. Its main office is located at Quezon Institute Compound, E. Rodriguez Sr., Avenue, Quezon City.
The Society operates the Quezon Institute (QI) Hospital and the Field Operations Division, which is in charge of tuberculosis pavilions, clinics and microscopy centers around the country. It is also pursuing a research and training program for complex cases of TB as a strategy to attract funding from local and foreign sources. The funding will substantially free the Society from subsidizing its services to TB indigents in the country.