In the early 1950s, the Brothers of De La Salle College-Manila, led by Br. H. Gabriel Connon FSC, acquired a six-hectare lot at Ortigas Avenue in Mandaluyong City to relocate the De La Salle Novitiate from Baguio and to accommodate increasing requests for admission to the then De La Salle Grade School at Taft Avenue, Manila.
In July 1959, La Salle Green Hills opened its doors to preparatory and grades 1 and 2 levels. Its first Brother-Director was Br. Alphonsus Bloemen FSC who first came to teach in De La Salle College in Manila in 1940.
On August 24, 1960, La Salle Green Hills, Inc. was registered as a non-stock, non-profit corporation with the Securities and Exchange Commission. In August 1964, the high school was established.
In 1968, when the De La Salle High School – Manila was made defunct, graduates of the De La Salle Grade School were transferred to the La Salle Green Hills High School, making La Salle Green Hills the high school of De La Salle University – Manila, until the establishment of the co-educational De La Salle-Santiago Zobel in 1978. Following the phase-out of De La Salle Grade School – Manila in 1984, its grade school graduates were given an option to study either at LSGH (for northern and central Metro Manila residents) or at De La Salle Zobel in Ayala Alabang Village (for southern Metro Manila residents).
La Salle Green Hills’ accreditation history speaks for itself – a mark of commitment to quality education. The Grade School Department’s Level III, 5-year certification (full curricular deregulation) in 2008, 2010, and 2015, not to mention its rare 7-year certification in 1993, from PAASCU and FAAP, attest to this.
This same brand of commitment manifests in the High School, cited as the 1st high school in the country to have been granted Level III PAASCU certification in 2003 and recipient of continuous accreditation status thereafter. In 2020, PAASCU granted the Grade School and the Adult Night High School with five-year Level III re-accreditation and five-year re-accreditation status, respectively.
On June 8, 2009, La Salle Green Hills celebrated its golden jubilee, and in 2011 celebrated together with the rest of the De La Salle schools in the Philippines the centennial celebration of the De La Salle Brothers in the Philippines.